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Protein kinases in control of the centrosome cycle

Stierhof, York-Dieter
Published in FEBS Letters. 1999, vol. 452, no. 1-2, p. 92-95
Abstract The centrosome is the major microtubule nucleating center of the animal cell and forms the two poles of the mitotic spindle upon which chromosomes are segregated. During the cell division cycle, the centrosome undergoes a series of major structural and functional transitions that are essential for both interphase centrosome function and mitotic spindle formation. The localization of an increasing number of protein kinases to the centrosome has revealed the importance of protein phosphorylation in controlling many of these transitions. Here, we focus on two protein kinases, the polo-like kinase 1 and the NIMA-related kinase 2, for which recent data indicate key roles during the centrosome cycle.
Keywords CentrosomeCell cyclePoloNIMANIMA-related kinase 2Centrosomal NIMA-related kinase 2-associated protein 1
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MAYOR, Thibault et al. Protein kinases in control of the centrosome cycle. In: FEBS Letters, 1999, vol. 452, n° 1-2, p. 92-95. doi: 10.1016/S0014-5793(99)00534-7 https://archive-ouverte.unige.ch/unige:129844

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Deposited on : 2020-01-31

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