UNIGE document Scientific Article
previous document  unige:129842  next document
add to browser collection
Title

The ins and outs of circadian timekeeping

Authors
Published in Current Opinion in Genetics & Development. 1999, vol. 9, no. 5, p. 588-594
Abstract Recent research in Drosophila and in mammals has generated fascinating new models for how circadian clocks in these organisms are reset by light and how these clocks, in turn, direct circadian outputs. Though light perception by the central clock is ocular in mammals, it probably proceeds via a mechanism separate from traditional visual transduction. In Drosophila, one mechanism is non-ocular and is in fact present in many different tissues. In both organisms, the cryptochrome family of photoreceptor-like molecules plays a role in the circadian clock, though their function is incompletely understood. Moreover, although a master clock resides in the brain, a functional clock appears to reside in most cells of the body. In these tissues, at least some output genes are controlled at the transcriptional level directly by clock proteins; others appear to be regulated by cascades of circadian transcription factors. Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks.
Identifiers
Full text
Structures
Citation
(ISO format)
BROWN, Steven, SCHIBLER, Ulrich. The ins and outs of circadian timekeeping. In: Current Opinion in Genetics & Development, 1999, vol. 9, n° 5, p. 588-594. doi: 10.1016/S0959-437X(99)00009-X https://archive-ouverte.unige.ch/unige:129842

20 hits

0 download

Update

Deposited on : 2020-01-31

Export document
Format :
Citation style :