Scientific article
Case report
Open access

11 C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia

Published inAnnals of Clinical and Translational Neurology, vol. 6, no. 10, p. 2133-2136
Publication date2019

There is evidence of increased microglial activation in Parkinson's disease (PD) as shown by in vivo PET ligand such as 11 C-PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson's disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher 11 C-PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions.

Citation (ISO format)
NICASTRO, Nicolas et al. <sup>11</sup> C-PK11195 PET imaging and white matter changes in Parkinson’s disease dementia. In: Annals of Clinical and Translational Neurology, 2019, vol. 6, n° 10, p. 2133–2136. doi: 10.1002/acn3.50877
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Article (Published version)
ISSN of the journal2328-9503

Technical informations

Creation11/29/2019 10:55:00 AM
First validation11/29/2019 10:55:00 AM
Update time03/15/2023 6:47:24 PM
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