Avoiding, reducing, and reversing land degradation and restoring degraded land is an urgent priority to protect the biodiversity and ecosystem services that are vital to life on Earth. To halt and reverse the current trends in land degradation, there is an immediate need to enhance national capacities to undertake quantitative assessments and mapping of their degraded lands, as required by the Sustainable Development Goals (SDGs), in particular, the SDG indicator 15.3.1 (“proportion of land that is degraded over total land area”). Earth Observations (EO) can play an important role both for generating this indicator as well as complementing or enhancing national official data sources. Implementations like Trends.Earth to monitor land degradation in accordance with the SDG15.3.1 rely on default datasets of coarse spatial resolution provided by MODIS or AVHRR. Consequently, there is a need to develop methodologies to benefit from medium to high-resolution satellite EO data (e.g. Landsat or Sentinels). In response to this issue, this paper presents an initial overview of an innovative approach to monitor land degradation at the national scale in compliance with the SDG15.3.1 indicator using Landsat observations using a data cube but further work is required to improve the calculation of the three sub-indicators.