Protocol for the validation of sensitivity and specificity of the Cow&#039;s Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants

Vandenplas, Yvan; Mukherjee, Rajat; Dupont, Christophe; Eigenmann, Philippe; Høst, Arne; Kuitunen, Mikael; Ribes-Koninkx, Carmen; Shah, Neil; Szajewska, Hania; von Berg, Andrea; Heine, Ralf G; Zhao, Zheng-Yan

doi:10.1136/bmjopen-2017-019968

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Title		Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants
Authors		Vandenplas, Yvan Mukherjee, Rajat Dupont, Christophe Eigenmann, Philippe Høst, Arne Kuitunen, Mikael Ribes-Koninkx, Carmen Shah, Neil Szajewska, Hania von Berg, Andrea Heine, Ralf G Zhao, Zheng-Yan show all authors [1 - 12]
Collaboration		Chinese CoMiSS Investigator Team
Published in		BMJ Open. 2018, vol. 8, no. 5, e019968
Abstract		The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA.
Keywords		Allergens/administration & dosage/adverse effects — Animals — Cattle — Decision Support Systems — Clinical/standards — Female — Humans — Infant — Infant — Newborn — Logistic Models — Male — Milk Hypersensitivity/diagnosis — Prospective Studies — Single-Blind Method — Validation Studies as Topic — Cow’s milk protein allergy — Diagnosis — Infant — Study design — Symptom score — Validation
Identifiers		DOI: 10.1136/bmjopen-2017-019968 PMID: 29773698
Full text		Article (Published version) (1.7 MB) - Free access Other version: https://bmjopen.bmj.com/content/8/5/e019968
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		Pathogenèse et traitement des allergies alimentaires (191)
Citation (ISO format)		VANDENPLAS, Yvan et al. Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants. In: BMJ Open, 2018, vol. 8, n° 5, p. e019968. doi: 10.1136/bmjopen-2017-019968 https://archive-ouverte.unige.ch/unige:128718