Scientific article
OA Policy
English

Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants

Published inBMJ Open, vol. 8, no. 5, e019968
Publication date2018
Abstract

The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA.

Keywords
  • Allergens/administration & dosage/adverse effects
  • Animals
  • Cattle
  • Decision Support Systems
  • Clinical/standards
  • Female
  • Humans
  • Infant
  • Infant
  • Newborn
  • Logistic Models
  • Male
  • Milk Hypersensitivity/diagnosis
  • Prospective Studies
  • Single-Blind Method
  • Validation Studies as Topic
  • Cow's milk protein allergy
  • Diagnosis
  • Infant
  • Study design
  • Symptom score
  • Validation
Citation (ISO format)
VANDENPLAS, Yvan et al. Protocol for the validation of sensitivity and specificity of the Cow’s Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants. In: BMJ Open, 2018, vol. 8, n° 5, p. e019968. doi: 10.1136/bmjopen-2017-019968
Main files (1)
Article (Published version)
Identifiers
Additional URL for this publicationhttps://bmjopen.bmj.com/content/8/5/e019968
Journal ISSN2044-6055
280views
179downloads

Technical informations

Creation04/11/2019 15:54:00
First validation04/11/2019 15:54:00
Update time15/03/2023 18:43:26
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