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Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants

Publié dansBMJ Open, vol. 8, no. 5, e019968
Date de publication2018
Résumé

The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA.

Mots-clés
  • Allergens/administration & dosage/adverse effects
  • Animals
  • Cattle
  • Decision Support Systems
  • Clinical/standards
  • Female
  • Humans
  • Infant
  • Infant
  • Newborn
  • Logistic Models
  • Male
  • Milk Hypersensitivity/diagnosis
  • Prospective Studies
  • Single-Blind Method
  • Validation Studies as Topic
  • Cow's milk protein allergy
  • Diagnosis
  • Infant
  • Study design
  • Symptom score
  • Validation
Citation (format ISO)
VANDENPLAS, Yvan et al. Protocol for the validation of sensitivity and specificity of the Cow’s Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants. In: BMJ Open, 2018, vol. 8, n° 5, p. e019968. doi: 10.1136/bmjopen-2017-019968
Fichiers principaux (1)
Article (Published version)
Identifiants
ISSN du journal2044-6055
236vues
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Informations techniques

Création04/11/2019 15:54:00
Première validation04/11/2019 15:54:00
Heure de mise à jour15/03/2023 18:43:26
Changement de statut15/03/2023 18:43:25
Dernière indexation05/05/2024 16:21:16
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