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Title

Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants

Authors
Vandenplas, Yvan
Mukherjee, Rajat
Dupont, Christophe
Høst, Arne
Kuitunen, Mikael
Ribes-Koninkx, Carmen
Shah, Neil
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Published in BMJ Open. 2018, vol. 8, no. 5, e019968
Abstract The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA.
Keywords Allergens/administration & dosage/adverse effectsAnimalsCattleDecision Support SystemsClinical/standardsFemaleHumansInfantInfantNewbornLogistic ModelsMaleMilk Hypersensitivity/diagnosisProspective StudiesSingle-Blind MethodValidation Studies as TopicCow’s milk protein allergyDiagnosisInfantStudy designSymptom scoreValidation
Identifiers
PMID: 29773698
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Research group Pathogenèse et traitement des allergies alimentaires (191)
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(ISO format)
VANDENPLAS, Yvan et al. Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants. In: BMJ Open, 2018, vol. 8, n° 5, p. e019968. doi: 10.1136/bmjopen-2017-019968 https://archive-ouverte.unige.ch/unige:128718

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Deposited on : 2020-01-13

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