Scientific article
Open access

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

Published inNew England Journal of Medicine, vol. 378, no. 25, p. 2376-2385
Publication date2018

Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival.

  • Adolescent
  • Child
  • Child
  • Preschool
  • Cisplatin/administration & dosage/adverse effects
  • Doxorubicin/administration & dosage
  • Drug Therapy
  • Combination
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Hearing Loss/chemically induced/prevention & control
  • Hepatoblastoma/drug therapy/mortality
  • Humans
  • Incidence
  • Infant
  • Liver Neoplasms/drug therapy/mortality
  • Male
  • Single-Blind Method
  • Survival Analysis
  • Thiosulfates/administration & dosage/adverse effects/therapeutic use
Citation (ISO format)
BROCK, Penelope R et al. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. In: New England Journal of Medicine, 2018, vol. 378, n° 25, p. 2376–2385. doi: 10.1056/NEJMoa1801109
Main files (1)
Article (Published version)
ISSN of the journal0028-4793

Technical informations

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