Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

Brock, Penelope R; Maibach, Rudolf; Childs, Margaret; Rajput, Kaukab; Roebuck, Derek; Sullivan, Michael J; Laithier, Véronique; Ronghe, Milind; Dall'Igna, Patrizia; Hiyama, Eiso; Brichard, Bénédicte; Skeen, Jane; Mateos, M Elena; Capra, Michael; Rangaswami, Arun A; Ansari Djaberi, Marc Georges; Rechnitzer, Catherine; Veal, Gareth J; Covezzoli, Anna; Brugières, Laurence; Perilongo, Giorgio; Czauderna, Piotr; Morland, Bruce; Neuwelt, Edward A

doi:10.1056/NEJMoa1801109

Scientific article

English

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

Published inNew England Journal of Medicine, vol. 378, no. 25, p. 2376-2385

Publication date2018

Abstract

Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival.

Keywords

Adolescent
Child
Child
Preschool
Cisplatin/administration & dosage/adverse effects
Doxorubicin/administration & dosage
Drug Therapy
Combination
Female
Follow-Up Studies
Glomerular Filtration Rate
Hearing Loss/chemically induced/prevention & control
Hepatoblastoma/drug therapy/mortality
Humans
Incidence
Infant
Liver Neoplasms/drug therapy/mortality
Male
Single-Blind Method
Survival Analysis
Thiosulfates/administration & dosage/adverse effects/therapeutic use

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

BROCK, Penelope R et al. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. In: New England Journal of Medicine, 2018, vol. 378, n° 25, p. 2376–2385. doi: 10.1056/NEJMoa1801109

Article (Published version)

Identifiers

PID : unige:128639
DOI : 10.1056/NEJMoa1801109
PMID : 29924955

Additional URL for this publicationhttps://www.nejm.org/doi/10.1056/NEJMoa1801109

Journal ISSN0028-4793

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Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss

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