Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

Karremann, Michael; Gielen, Gerrit H; Hoffmann, Marion; Wiese, Maria; Colditz, Niclas; Warmuth-Metz, Monika; Bison, Brigitte; Claviez, Alexander; van Vuurden, Dannis G; Von Bueren, André; Gessi, Marco; Kühnle, Ingrid; Hans, Volkmar H; Benesch, Martin; Sturm, Dominik; Kortmann, Rolf-Dieter; Waha, Andreas; Pietsch, Torsten; Kramm, Christof M

doi:10.1093/neuonc/nox149

Scientific article

English

Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

ContributorsKarremann, Michael; Gielen, Gerrit H; Hoffmann, Marion; Wiese, Maria; Colditz, Niclas; Warmuth-Metz, Monika; Bison, Brigitte; Claviez, Alexander; van Vuurden, Dannis G; Von Bueren, André

; Gessi, Marco; Kühnle, Ingrid; Hans, Volkmar H; Benesch, Martin; Sturm, Dominik; Kortmann, Rolf-Dieter; Waha, Andreas; Pietsch, Torsten; Kramm, Christof M

Published inNeuro-Oncology, vol. 20, no. 1, p. 123-131

Publication date2018

Abstract

The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of predominantly pediatric patients and are associated with an overall dismal prognosis. They are defined by K27M mutations in H3F3A or HIST1H3B/C, encoding for histone 3 variants H3.3 and H3.1, respectively, which are considered hallmark events driving gliomagenesis.

Keywords

Adolescent
Brain Neoplasms/diagnosis/genetics/pathology
Child
Female
Glioma/diagnosis/genetics/pathology
Histones/genetics
Humans
Male
Mutation/genetics
Neoplasm Grading
Prognosis
K27M mutation
Children
Diffuse midline glioma
High-grade glioma
Histone H3

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

KARREMANN, Michael et al. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. In: Neuro-Oncology, 2018, vol. 20, n° 1, p. 123–131. doi: 10.1093/neuonc/nox149

Article (Published version)

Identifiers

PID : unige:128636
DOI : 10.1093/neuonc/nox149
PMID : 29016894

Commercial URLhttps://academic.oup.com/neuro-oncology/article/20/1/123/4064721

Datasets

https://academic.oup.com/neuro-oncology/article/20/1/123/4064721#supplementary-data

Journal ISSN1522-8517

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Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

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