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Title

Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

Authors
Karremann, Michael
Gielen, Gerrit H
Hoffmann, Marion
Wiese, Maria
Colditz, Niclas
Warmuth-Metz, Monika
Bison, Brigitte
Claviez, Alexander
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Published in Neuro-Oncology. 2018, vol. 20, no. 1, p. 123-131
Abstract The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of predominantly pediatric patients and are associated with an overall dismal prognosis. They are defined by K27M mutations in H3F3A or HIST1H3B/C, encoding for histone 3 variants H3.3 and H3.1, respectively, which are considered hallmark events driving gliomagenesis.
Keywords AdolescentBrain Neoplasms/diagnosis/genetics/pathologyChildFemaleGlioma/diagnosis/genetics/pathologyHistones/geneticsHumansMaleMutation/geneticsNeoplasm GradingPrognosisK27M mutationChildrenDiffuse midline gliomaHigh-grade gliomaHistone H3
Identifiers
PMID: 29016894
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Research group Oncologie et hématologie pédiatrique (907)
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KARREMANN, Michael et al. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. In: Neuro-Oncology, 2018, vol. 20, n° 1, p. 123-131. doi: 10.1093/neuonc/nox149 https://archive-ouverte.unige.ch/unige:128636

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Deposited on : 2020-01-10

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