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Title

Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges

Authors
Danziger-Isakov, Lara
Englund, Janet
Green, Michael
Zerr, Danielle M
Published in Journal of the Pediatric Infectious Diseases Society. 2018, vol. 7, no. suppl_2, p. S72-S74
Abstract Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation.
Keywords Antiviral Agents/therapeutic useChildCytomegalovirus/immunologyCytomegalovirus Infections/complications/prevention & control/virologyDrug ResistanceViralFatal OutcomeFoscarnet/therapeutic useGranulomatous DiseaseChronic/complications/therapyHematopoietic Stem Cell TransplantationHumansMaleRecurrenceRespiratory Insufficiency/etiologyRisk AssessmentSecondary PreventionT-LymphocytesCytotoxicValganciclovir/therapeutic useViral Load
Identifiers
PMID: 30590625
Full text
Article (Published version) (165 Kb) - public document Free access
Structures
Research group Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
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(ISO format)
DANZIGER-ISAKOV, Lara et al. Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges. In: Journal of the Pediatric Infectious Diseases Society, 2018, vol. 7, n° suppl_2, p. S72-S74. doi: 10.1093/jpids/piy104 https://archive-ouverte.unige.ch/unige:128634

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Deposited on : 2020-01-10

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