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Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges |
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Published in | Journal of the Pediatric Infectious Diseases Society. 2018, vol. 7, no. suppl_2, p. S72-S74 | |
Abstract | Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation. | |
Keywords | Antiviral Agents/therapeutic use — Child — Cytomegalovirus/immunology — Cytomegalovirus Infections/complications/prevention & control/virology — Drug Resistance — Viral — Fatal Outcome — Foscarnet/therapeutic use — Granulomatous Disease — Chronic/complications/therapy — Hematopoietic Stem Cell Transplantation — Humans — Male — Recurrence — Respiratory Insufficiency/etiology — Risk Assessment — Secondary Prevention — T-Lymphocytes — Cytotoxic — Valganciclovir/therapeutic use — Viral Load | |
Identifiers | DOI: 10.1093/jpids/piy104 PMID: 30590625 | |
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Research group | Recherche en infectiologie pédiatrique et en pédiatrie générale (853) | |
Citation (ISO format) | DANZIGER-ISAKOV, Lara et al. Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges. In: Journal of the Pediatric Infectious Diseases Society, 2018, vol. 7, n° suppl_2, p. S72-S74. doi: 10.1093/jpids/piy104 https://archive-ouverte.unige.ch/unige:128634 |