Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges

Danziger-Isakov, Lara; Englund, Janet; Green, Michael; Posfay Barbe, Klara; Zerr, Danielle M

doi:10.1093/jpids/piy104

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges
Authors		Danziger-Isakov, Lara Englund, Janet Green, Michael Posfay Barbe, Klara Zerr, Danielle M
Published in		Journal of the Pediatric Infectious Diseases Society. 2018, vol. 7, no. suppl_2, p. S72-S74
Abstract		Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation.
Keywords		Antiviral Agents/therapeutic use — Child — Cytomegalovirus/immunology — Cytomegalovirus Infections/complications/prevention & control/virology — Drug Resistance — Viral — Fatal Outcome — Foscarnet/therapeutic use — Granulomatous Disease — Chronic/complications/therapy — Hematopoietic Stem Cell Transplantation — Humans — Male — Recurrence — Respiratory Insufficiency/etiology — Risk Assessment — Secondary Prevention — T-Lymphocytes — Cytotoxic — Valganciclovir/therapeutic use — Viral Load
Identifiers		DOI: 10.1093/jpids/piy104 PMID: 30590625
Full text		Article (Published version) (165 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Citation (ISO format)		DANZIGER-ISAKOV, Lara et al. Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges. In: Journal of the Pediatric Infectious Diseases Society, 2018, vol. 7, n° suppl_2, p. S72-S74. doi: 10.1093/jpids/piy104 https://archive-ouverte.unige.ch/unige:128634