en
Scientific article
Open access
English

Immune monitoring after pediatric liver transplantation - the prospective ChilSFree cohort study

Published inBMC Gastroenterology, vol. 18, no. 1, 63
Publication date2018
Abstract

Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessment of functional degree of immunosuppression or the identification of clinically relevant over- or under-immunosuppression, depending on graft homeostasis. Reliable non-invasive markers to predict biopsy proven acute rejection (BPAR) do not exist. Literature data suggest that longitudinal measurements of immune markers might be predictive of BPAR, but data in children are scarce. We therefore propose an observational prospective cohort study focusing on immune monitoring in children after liver transplantation. We aim to describe immune function in a cohort of children before and during the first year after liver transplantation and plan to investigate how the immune function profile is associated with clinical and laboratory findings.

Keywords
  • Adolescent
  • Angiogenic Proteins/blood
  • Biomarkers/blood
  • Biopsy
  • Chemokines/blood
  • Child
  • Child
  • Preschool
  • Cytokines/blood
  • Female
  • Graft Rejection
  • Humans
  • Immunosuppressive Agents/therapeutic use
  • Infant
  • Kidney Failure
  • Chronic/surgery
  • Liver Transplantation
  • Longitudinal Studies
  • Male
  • Monitoring
  • Immunologic
  • Postoperative Period
  • Prospective Studies
  • Immune monitoring
  • Paediatric liver transplantation
  • Rejection
Citation (ISO format)
GOLDSCHMIDT, Imeke et al. Immune monitoring after pediatric liver transplantation - the prospective ChilSFree cohort study. In: BMC Gastroenterology, 2018, vol. 18, n° 1, p. 63. doi: 10.1186/s12876-018-0795-x
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1471-230X
247views
83downloads

Technical informations

Creation2019.11.05. 오전 11:19:00
First validation2019.11.05. 오전 11:19:00
Update time2023.03.15. 오후 6:41:08
Status update2023.03.15. 오후 6:41:07
Last indexation2024.02.12. 오전 11:46:07
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack