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Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Mouraux, Stéphane
Bernasconi, Eric
Pattaroni, Céline
Koutsokera, Angela
Aubert, John-David
Claustre, Johanna
Pison, Christophe
Royer, Pierre-Joseph
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CollaborationWith : Rochat, Thierry / Licker, Marc
Published in Journal of Allergy and Clinical Immunology. 2018, vol. 141, no. 2, p. 718-729.e7
Abstract Homeostatic turnover of the extracellular matrix conditions the structure and function of the healthy lung. In lung transplantation, long-term management remains limited by chronic lung allograft dysfunction, an umbrella term used for a heterogeneous entity ultimately associated with pathological airway and/or parenchyma remodeling.
Keywords AdultAirway Remodeling/immunologyBacteria/classification/immunologyExtracellular Matrix/immunology/pathologyFemaleFibroblasts/immunology/pathologyHumansLung/immunology/microbiology/pathologyLung TransplantationMacrophages/immunology/pathologyMaleMicrobiota/immunologyMiddle AgedSignal Transduction/immunologyAirway remodelingFibroblastsMacrophagesMatrixMicrobiota
PMID: 28729000
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Research group Groupe Gasche-Soccal Paola (958)
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MOURAUX, Stéphane et al. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung. In: Journal of Allergy and Clinical Immunology, 2018, vol. 141, n° 2, p. 718-729.e7. doi: 10.1016/j.jaci.2017.06.022 https://archive-ouverte.unige.ch/unige:128492

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Deposited on : 2020-01-08

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