UNIGE document Scientific Article
previous document  unige:128487  next document
add to browser collection

Factors associated with immune hemolytic anemia after pediatric liver transplantation

Published in Pediatric Transplantation. 2018, vol. 22, no. 5, e13230
Abstract Immune-mediated hemolytic anemia following SOT is a rare disorder, the risk factors for which are unknown. Our purpose was to analyze a seemingly increased incidence in our center with the aim to identify predisposing factors. This recipients single-center retrospective study reviewed the medical records of 96 pediatric LT between 2000 and 2013. IHA was defined as acute anemia with a positive direct antiglobulin test. Seven cases of immune-mediated hemolytic anemia were identified (incidence 8.5%). Three cases presented during the first 3 months following LT (early IHA), and 4 presented later (late IHA). All patients with late IHA required rituximab. Using univariate analysis, the following factors were associated with IHA onset: BA (P = .04), younger age (P = .04), and the use of IGL-1 preservation solution (P = .05). Late IHA was associated with viral infections occurring beyond 3 months following LT, younger age, and BA (P = .01). Overall, CMV infection was associated with the development of both early and late IHA: CMV-negative recipients who received an organ from a CMV-positive donor were more likely to develop IHA (P = .035), and de novo CMV infection during the first year post-LT was associated with late IHA (P = .03). IHA is a rare complication following pediatric LT, occurring more frequently in younger patients and patients with an initial diagnosis of BA. CMV-negative recipients and patients who experience a de novo CMV infection in the first year following LT seem particularly vulnerable. IGL-1 preservation solution may be associated with an increased likelihood of developing IHA, a novel finding which warrants further investigation.
Keywords AnemiaHemolyticAutoimmune/diagnosis/epidemiology/etiologyChildChildPreschoolFemaleFollow-Up StudiesHumansIncidenceInfantLiver TransplantationMaleOutcome Assessment (Health Care)Postoperative Complications/diagnosis/epidemiology/etiologyRetrospective StudiesRisk FactorsEvans syndromeAnemiaAutoimmuneAutoimmunityHemolyticLiver transplantationPediatrics
PMID: 29885007
Full text
Article (Published version) (318 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Développement du tube digestif chez les vertébrés (900)
Oncologie et hématologie pédiatrique (907)
Transplantation immunologie et osteoimmunologie (561)
(ISO format)
ROCK, Nathalie et al. Factors associated with immune hemolytic anemia after pediatric liver transplantation. In: Pediatric Transplantation, 2018, vol. 22, n° 5, p. e13230. doi: 10.1111/petr.13230 https://archive-ouverte.unige.ch/unige:128487

235 hits

1 download


Deposited on : 2020-01-08

Export document
Format :
Citation style :