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Titles listFactors associated with immune hemolytic anemia after pediatric liver transplantation
Titles listFactors associated with immune hemolytic anemia after pediatric liver transplantation
Scientific Article
unige:128487 
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Factors associated with immune hemolytic anemia after pediatric liver transplantation |
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| Authors | ||
| Published in | Pediatric Transplantation. 2018, vol. 22, no. 5, e13230 | |
| Abstract | Immune-mediated hemolytic anemia following SOT is a rare disorder, the risk factors for which are unknown. Our purpose was to analyze a seemingly increased incidence in our center with the aim to identify predisposing factors. This recipients single-center retrospective study reviewed the medical records of 96 pediatric LT between 2000 and 2013. IHA was defined as acute anemia with a positive direct antiglobulin test. Seven cases of immune-mediated hemolytic anemia were identified (incidence 8.5%). Three cases presented during the first 3 months following LT (early IHA), and 4 presented later (late IHA). All patients with late IHA required rituximab. Using univariate analysis, the following factors were associated with IHA onset: BA (P = .04), younger age (P = .04), and the use of IGL-1 preservation solution (P = .05). Late IHA was associated with viral infections occurring beyond 3 months following LT, younger age, and BA (P = .01). Overall, CMV infection was associated with the development of both early and late IHA: CMV-negative recipients who received an organ from a CMV-positive donor were more likely to develop IHA (P = .035), and de novo CMV infection during the first year post-LT was associated with late IHA (P = .03). IHA is a rare complication following pediatric LT, occurring more frequently in younger patients and patients with an initial diagnosis of BA. CMV-negative recipients and patients who experience a de novo CMV infection in the first year following LT seem particularly vulnerable. IGL-1 preservation solution may be associated with an increased likelihood of developing IHA, a novel finding which warrants further investigation. | |
| Keywords | Anemia — Hemolytic — Autoimmune/diagnosis/epidemiology/etiology — Child — Child — Preschool — Female — Follow-Up Studies — Humans — Incidence — Infant — Liver Transplantation — Male — Outcome Assessment (Health Care) — Postoperative Complications/diagnosis/epidemiology/etiology — Retrospective Studies — Risk Factors — Evans syndrome — Anemia — Autoimmune — Autoimmunity — Hemolytic — Liver transplantation — Pediatrics | |
| Identifiers | DOI: 10.1111/petr.13230 PMID: 29885007 | |
| Full text | ||
| Structures | ||
| Research groups | Développement du tube digestif chez les vertébrés (900) Oncologie et hématologie pédiatrique (907) Transplantation immunologie et osteoimmunologie (561) | |
| Citation (ISO format) | ROCK, Nathalie et al. Factors associated with immune hemolytic anemia after pediatric liver transplantation. In: Pediatric Transplantation, 2018, vol. 22, n° 5, p. e13230. doi: 10.1111/petr.13230 https://archive-ouverte.unige.ch/unige:128487 |
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