UNIGE document Scientific Article
previous document  unige:1284  next document
add to browser collection

Working memory impairments in first-episode psychosis and chronic schizophrenia

Curtis, Logos
Published in Psychiatry research. 2009, vol. 165, no. 1-2, p. 10-8
Abstract Working memory (WM) impairments are core cognitive deficits in patients with schizophrenia linked to prefrontal cortical dysfunctions. Determining the differences between early phases of illness allows a better understanding of its course and constitutes an important guide for treatment. The present cross-sectional study examined differences of working memory functions between 33 first-episode and 29 chronic schizophrenic patients, as well as 64 healthy controls. On the basis of a two-back visual-verbal computerized working memory task, reaction time was slower and accuracy was worse in both patient groups than in controls. Test variables, however, were not significantly different between the patient groups, suggesting stability of the deficits over time. Effect size accuracy variables nevertheless showed larger deficits in chronic patients.
Keywords Acute DiseaseAdolescentAdultAttentionCase-Control StudiesChronic DiseaseCognition Disorders/diagnosis/psychologyFemaleHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPsychotic Disorders/diagnosis/psychologyReaction TimeSchizophrenia/diagnosisSchizophrenic PsychologyYoung Adult
PMID: 19046607
Full text
Article (Accepted version) (253 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
ZANELLO, Adriano et al. Working memory impairments in first-episode psychosis and chronic schizophrenia. In: Psychiatry research, 2009, vol. 165, n° 1-2, p. 10-8. doi: 10.1016/j.psychres.2007.10.006 https://archive-ouverte.unige.ch/unige:1284

507 hits



Deposited on : 2009-04-01

Export document
Format :
Citation style :