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Title

A comparison of Sensititre™ Anaerobe MIC plate with ATB ANA® test for the routine susceptibility testing of common anaerobe pathogens

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Published in European Journal of Clinical Microbiology & Infectious Diseases. 2018, vol. 37, no. 12, p. 2279-2284
Abstract The accuracy of the Thermo Scientific™ Sensititre™ Anaerobe MIC plate was assessed against the ATB ANA® test (bioMérieux) on 56 clinically relevant anaerobic strains collected at Geneva University Hospitals. The overall categorical agreement between both methods reached 95%. The Sensititre™ Anaerobe MIC plate had excellent accuracy for most antibiotics tested. When the Sensititre™ Anaerobe MIC plate disagreed with ATB ANA® test, the gradient strip method resolved the antimicrobial susceptibility categories of all the antibiotics tested, except for piperacillin, piperacillin-tazobactam, and penicillin, in favor of the Sensititre™ Anaerobe MIC plate (58% [21 out of 36]). Several very major errors were observed for piperacillin (12.5% [7 out of 56]), piperacillin-tazobactam (12.5% [7 out of 56]), and penicillin (2% [1 out of 56]). The gradient strip method revealed that the categorical differences for piperacillin, piperacillin-tazobactam, and penicillin were at least partly explained by heterogeneity in resistance expression. The Sensititre™ Anaerobe MIC plate offers therefore a useful alternative to the ATB ANA® test for the routine antimicrobial susceptibility testing of anaerobes in clinical microbiology laboratories.
Keywords Anti-Bacterial Agents/pharmacologyBacteriaAnaerobic/drug effectsCross Infection/microbiologyGram-Negative Bacteria/drug effectsGram-Positive Bacteria/drug effectsMicrobial Sensitivity Tests/instrumentation/methodsPenicillins/pharmacologyPiperacillin/pharmacologySwitzerland
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PMID: 30191340
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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CHERKAOUI, Abdessalam et al. A comparison of Sensititre™ Anaerobe MIC plate with ATB ANA® test for the routine susceptibility testing of common anaerobe pathogens. In: European Journal of Clinical Microbiology & Infectious Diseases, 2018, vol. 37, n° 12, p. 2279-2284. doi: 10.1007/s10096-018-3369-5 https://archive-ouverte.unige.ch/unige:128182

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Deposited on : 2019-12-23

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