New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

CHARGE EXOME BP Consortium; CHD Exome+ Consortium; Exome BP Consortium; GoT2D:T2DGenes Consortium; The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group

doi:10.1161/CIRCGENETICS.117.001778

Scientific article

Meta-analysis

English

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

ContributorsCHARGE EXOME BP Consortium; CHD Exome+ Consortium; Exome BP Consortium; GoT2D:T2DGenes Consortium; The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group

CollaboratorsEhret, Georg Benedikt

Published inCirculation: Cardiovascular Genetics, vol. 10, no. 5, e001778

Publication date2017

Abstract

Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association.

Keywords

Antiporters/genetics
Blood Pressure/genetics
Cell Adhesion Molecules
Neuronal/genetics
Databases
Factual
Genetic Loci
Genome-Wide Association Study
Genotype
Humans
Microfilament Proteins/genetics
Phenotype
Polymorphism
Single Nucleotide
Receptors
Lymphocyte Homing/genetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Génétique (901)

Citation (ISO format)

CHARGE EXOME BP Consortium et al. New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. In: Circulation: Cardiovascular Genetics, 2017, vol. 10, n° 5, p. e001778. doi: 10.1161/CIRCGENETICS.117.001778