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Title

Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales

Authors
Fumagalli, Giorgio G
Basilico, Paola
Arighi, Andrea
Bocchetta, Martina
Dick, Katrina M
Cash, David M
Harding, Sophie
Mercurio, Matteo
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Published in Alzheimer's Research and Therapy. 2018, vol. 10, no. 1, p. 46
Abstract In patients with frontotemporal dementia, it has been shown that brain atrophy occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating scales to investigate whether identifying atrophy in these areas may be helpful in distinguishing symptomatic patients carrying different causal mutations in the microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame (C9ORF72) genes. We also analysed asymptomatic carriers to see whether it was possible to visually identify brain atrophy before the appearance of symptoms.
Keywords AdultAtrophy/classification/diagnostic imaging/etiologyBrain/diagnostic imaging/pathologyCohort StudiesFemaleFrontotemporal Dementia/complications/diagnostic imaging/geneticsHumansInternational CooperationMagnetic Resonance ImagingMaleMiddle AgedProgranulins/geneticsRNA-Binding Proteins/geneticsSeverity of Illness IndexStatisticsNonparametricTau Proteins/genetics
Identifiers
PMID: 29793546
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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FUMAGALLI, Giorgio G et al. Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales. In: Alzheimer's Research and Therapy, 2018, vol. 10, n° 1, p. 46. doi: 10.1186/s13195-018-0376-9 https://archive-ouverte.unige.ch/unige:128076

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Deposited on : 2019-12-18

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