Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales

Fumagalli, Giorgio G; Basilico, Paola; Arighi, Andrea; Bocchetta, Martina; Dick, Katrina M; Cash, David M; Harding, Sophie; Mercurio, Matteo; Fenoglio, Chiara; Pietroboni, Anna M; Ghezzi, Laura; van Swieten, John; Borroni, Barbara; de Mendonça, Alexandre; Masellis, Mario; Tartaglia, Maria C; Rowe, James B; Graff, Caroline; Tagliavini, Fabrizio; Frisoni, Giovanni; Laforce, Robert (Jr); Finger, Elizabeth; Sorbi, Sandro; Scarpini, Elio; Rohrer, Jonathan D; Galimberti, Daniela

doi:10.1186/s13195-018-0376-9

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Title		Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales
Authors		Fumagalli, Giorgio G Basilico, Paola Arighi, Andrea Bocchetta, Martina Dick, Katrina M Cash, David M Harding, Sophie Mercurio, Matteo Fenoglio, Chiara Pietroboni, Anna M Ghezzi, Laura van Swieten, John Borroni, Barbara de Mendonça, Alexandre Masellis, Mario Tartaglia, Maria C Rowe, James B Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni Laforce, Robert (Jr) Finger, Elizabeth Sorbi, Sandro Scarpini, Elio Rohrer, Jonathan D Galimberti, Daniela show all authors [1 - 26]
Collaboration		Genetic FTD Initiative (GENFI)
Published in		Alzheimer's Research and Therapy. 2018, vol. 10, no. 1, p. 46
Abstract		In patients with frontotemporal dementia, it has been shown that brain atrophy occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating scales to investigate whether identifying atrophy in these areas may be helpful in distinguishing symptomatic patients carrying different causal mutations in the microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame (C9ORF72) genes. We also analysed asymptomatic carriers to see whether it was possible to visually identify brain atrophy before the appearance of symptoms.
Keywords		Adult — Atrophy/classification/diagnostic imaging/etiology — Brain/diagnostic imaging/pathology — Cohort Studies — Female — Frontotemporal Dementia/complications/diagnostic imaging/genetics — Humans — International Cooperation — Magnetic Resonance Imaging — Male — Middle Aged — Progranulins/genetics — RNA-Binding Proteins/genetics — Severity of Illness Index — Statistics — Nonparametric — Tau Proteins/genetics
Identifiers		DOI: 10.1186/s13195-018-0376-9 PMID: 29793546
Full text		Article (Published version) (1 MB) - Free access Other version: https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0376-9
Structures		Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		FUMAGALLI, Giorgio G et al. Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales. In: Alzheimer's Research and Therapy, 2018, vol. 10, n° 1, p. 46. doi: 10.1186/s13195-018-0376-9 https://archive-ouverte.unige.ch/unige:128076