en
Scientific article
Open access
English

Impact of Real-Time Therapeutic Drug Monitoring on the Prescription of Antibiotics in Burn Patients Requiring Admission to the Intensive Care Unit

Published inAntimicrobial Agents and Chemotherapy, vol. 62, no. 3
Publication date2018
Abstract

As pharmacokinetics after burn trauma are difficult to predict, we conducted a 3-year prospective, monocentric, randomized, controlled trial to determine the extent of under- and overdosing of antibiotics and further evaluate the impact of systematic therapeutic drug monitoring (TDM) with same-day real-time dose adaptation to reach and maintain antibiotic concentrations within the therapeutic range. Forty-five consecutive burn patients treated with antibiotics were prospectively screened. Forty fulfilled the inclusion criteria; after one patient refused to participate and one withdrew consent, 19 were randomly assigned to an intervention group (patients with real-time antibiotic concentration determination and subsequent adaptations) and 19 were randomly assigned to a standard-of-care group (patients with antibiotic administration at the physician's discretion without real-time TDM). Seventy-three infection episodes were analyzed. Before the intervention, only 46/82 (56%) initial trough concentrations fell within the range. There was no difference between groups in the initial trough concentrations (adjusted hazard ratio = 1.39 [95% confidence interval {CI}, 0.81 to 2.39], P = 0.227) or the time to reach the target. However, thanks to real-time dose adjustments, the trough concentrations of the intervention group remained more within the predefined range (57/77 [74.0%] versus 48/85 [56.5%]; adjusted odd ratio [OR] = 2.34 [95% CI, 1.17 to 4.81], P = 0.018), more days were spent within the target range (193 days/297 days on antibiotics [65.0%] versus 171 days/311 days in antibiotics [55.0%]; adjusted OR = 1.64 [95% CI, 1.16 to 2.32], P = 0.005), and fewer results were below the target trough concentrations (25/118 [21.2%] versus 44/126 [34.9%]; adjusted OR = 0.47 [95% CI, 0.26 to 0.87], P = 0.015). No difference in infection outcomes was observed between the study groups. Systematic TDM with same-day real-time dose adaptation was effective in reaching and maintaining therapeutic antibiotic concentrations in infected burn patients, which prevented both over- and underdosing. A larger multicentric study is needed to further evaluate the impact of this strategy on infection outcomes and the emergence of antibiotic resistance during long-term burn treatment. (This study was registered with the ClinicalTrials.gov platform under registration no. NCT01965340 on 27 September 2013.).

Keywords
  • Adult
  • Aged
  • 80 and over
  • Anti-Bacterial Agents/therapeutic use
  • Burns/drug therapy
  • Drug Monitoring/methods
  • Female
  • Humans
  • Intensive Care Units/statistics & numerical data
  • Male
  • Middle Aged
  • Prospective Studies
  • Young Adult
Citation (ISO format)
FOURNIER, Anne et al. Impact of Real-Time Therapeutic Drug Monitoring on the Prescription of Antibiotics in Burn Patients Requiring Admission to the Intensive Care Unit. In: Antimicrobial Agents and Chemotherapy, 2018, vol. 62, n° 3. doi: 10.1128/AAC.01818-17
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0066-4804
246views
96downloads

Technical informations

Creation10/11/2019 4:45:00 PM
First validation10/11/2019 4:45:00 PM
Update time03/15/2023 6:35:04 PM
Status update03/15/2023 6:35:03 PM
Last indexation02/12/2024 1:08:21 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack