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Title

Organization of the Higher-Order Chromatin Loop: Specific DNA Attachment Sites on Nuclear Scaffold

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Mirault, Marc-Edouard
Published in Cell. 1984, vol. 39, no. 1, p. 223-232
Abstract Data are presented for sequence-specific chromatin-loop organization in histone-depleted nuclei from Drosophila melanogaster Kc cells. We find one loop for each of the tandemly repeated histone gene clusters. The attachment site is localized in the A + T rich H1-H3 spacer on a 657 bp fragment. In the cluster of the hsp70 heat-shock genes, in both control and heat-shocked cells, we find two attachment sites in close proximity upstream of regulatory elements. The transcribed sequences are not associated with the nuclear scaffold in control or in heat-shocked cells. A family of attachment sites related by hybridization to those of the hsp70 genes was discovered.
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MIRKOVITCH, Jovan, MIRAULT, Marc-Edouard, LAEMMLI, Ulrich Karl. Organization of the Higher-Order Chromatin Loop: Specific DNA Attachment Sites on Nuclear Scaffold. In: Cell, 1984, vol. 39, n° 1, p. 223-232. doi: 10.1016/0092-8674(84)90208-3 https://archive-ouverte.unige.ch/unige:127860

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Deposited on : 2019-12-13

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