Scientific article
Meta-analysis
English

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations

Published inInternational Journal of Obesity, vol. 41, no. 2, p. 324-331
Publication date2017
Abstract

Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition.

Keywords
  • Adiposity/genetics
  • Adult
  • African Continental Ancestry Group/genetics
  • Body Fat Distribution
  • European Continental Ancestry Group/genetics
  • Female
  • Genetic Predisposition to Disease/ethnology
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Obesity
  • Abdominal/ethnology/genetics
  • Polymorphism
  • Single Nucleotide/genetics
  • Waist-Hip Ratio
Research groups
Citation (ISO format)
YONEYAMA, S et al. Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. In: International Journal of Obesity, 2017, vol. 41, n° 2, p. 324–331. doi: 10.1038/ijo.2016.207
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0307-0565
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