Scientific article
English

Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk Chronic Lymphocytic Leukemia

Published inClinical Lymphoma Myeloma and Leukemia, vol. 17, no. 10, p. 667-675.e2
Publication date2017
Abstract

Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free survival (PFS) with kinase- and BCL2-inhibitors (KI, BCL2i). Allogeneic hematopoietic stem cell transplantation (alloHCT) may result in sustained PFS, especially in younger patients because of its age-dependent non-relapse mortality (NRM) risk, but outcome data are lacking for this population.

Keywords
  • Adult
  • Aged
  • Chromosome Aberrations
  • Female
  • HLA Antigens
  • Hematopoietic Stem Cell Transplantation/adverse effects/methods
  • Humans
  • Kaplan-Meier Estimate
  • Leukemia
  • Lymphocytic
  • Chronic
  • B-Cell/diagnosis/genetics/mortality/therapy
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Tissue Donors
  • Transplantation Conditioning/adverse effects/methods
  • Transplantation
  • Homologous
  • Treatment Outcome
NoteA Retrospective Analysis From the Chronic Malignancies Working Party of the EBMT.
Citation (ISO format)
VAN GELDER, Michel et al. Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk Chronic Lymphocytic Leukemia. In: Clinical Lymphoma Myeloma and Leukemia, 2017, vol. 17, n° 10, p. 667–675.e2. doi: 10.1016/j.clml.2017.06.007
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN2152-2650
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