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Title

Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk Chronic Lymphocytic Leukemia

Authors
van Gelder, Michel
Ziagkos, Dimitris
de Wreede, Liesbeth
van Biezen, Anja
Dreger, Peter
Gramatzki, Martin
Stelljes, Matthias
Andersen, Niels Smedegaard
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Collaboration
Published in Clinical Lymphoma Myeloma and Leukemia. 2017, vol. 17, no. 10, p. 667-675.e2
Abstract Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free survival (PFS) with kinase- and BCL2-inhibitors (KI, BCL2i). Allogeneic hematopoietic stem cell transplantation (alloHCT) may result in sustained PFS, especially in younger patients because of its age-dependent non-relapse mortality (NRM) risk, but outcome data are lacking for this population.
Keywords AdultAgedChromosome AberrationsFemaleHLA AntigensHematopoietic Stem Cell Transplantation/adverse effects/methodsHumansKaplan-Meier EstimateLeukemiaLymphocyticChronicB-Cell/diagnosis/genetics/mortality/therapyMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsTissue DonorsTransplantation Conditioning/adverse effects/methodsTransplantationHomologousTreatment Outcome
Identifiers
PMID: 28694085
Note A Retrospective Analysis From the Chronic Malignancies Working Party of the EBMT.
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Structures
Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation
(ISO format)
VAN GELDER, Michel et al. Baseline Characteristics Predicting Very Good Outcome of Allogeneic Hematopoietic Cell Transplantation in Young Patients With High Cytogenetic Risk Chronic Lymphocytic Leukemia. In: Clinical Lymphoma Myeloma and Leukemia, 2017, vol. 17, n° 10, p. 667-675.e2. doi: 10.1016/j.clml.2017.06.007 https://archive-ouverte.unige.ch/unige:127784

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Deposited on : 2019-12-11

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