Scientific article
English

Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation

Published inBritish Journal of Haematology, vol. 177, no. 5, p. 759-765
Publication date2017
Abstract

Atypical chronic myeloid leukaemia (aCML) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (EBMT) registry who underwent allo-HSCT for aCML between 1997 and 2006. Median age was 46 years. Median time from diagnosis to transplant was 7 months. Disease status was first chronic phase in 69%. Donors were human leucocyte antigen (HLA)-identical siblings in 64% and matched unrelated (MUD) in 36%. A reduced intensity conditioning was employed in 24% of patients. T-cell depletion was applied in 87% and 26% of transplants from MUD and HLA-identical siblings, respectively. According to the EBMT risk-score, 45% of patients were 'low-risk', 31% 'intermediate-risk' and 24% 'high-risk'. Following allo-HSCT, 87% of patients achieved complete remission. At 5 years, relapse-free survival was 36% and non-relapse mortality (NRM) was 24%, while relapse occurred in 40%. Patient age and the EBMT score had an impact on overall survival. Relapse-free survival was higher in MUD than in HLA-identical sibling HSCT, with no difference in NRM. In conclusion, this study confirmed that allo-HSCT represents a valid strategy to achieve cure in a reasonable proportion of patients with aCML, with young patients with low EBMT risk score being the best candidates.

Keywords
  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Graft Survival
  • Hematopoietic Stem Cell Transplantation/methods/mortality
  • Humans
  • Leukemia
  • Myeloid
  • Chronic
  • Atypical
  • BCR-ABL Negative/mortality/therapy
  • Male
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Transplantation
  • Homologous
Citation (ISO format)
ONIDA, Francesco et al. Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation. In: British Journal of Haematology, 2017, vol. 177, n° 5, p. 759–765. doi: 10.1111/bjh.14619
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0007-1048
249views
0downloads

Technical informations

Creation11/21/2019 4:48:00 PM
First validation11/21/2019 4:48:00 PM
Update time03/15/2023 6:33:41 PM
Status update03/15/2023 6:33:40 PM
Last indexation10/31/2024 5:13:08 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack