Due to its specific location and functions, the liver is a primary target for blood alterations. In spite of its regenerative abilities allowing it to avoid major acute injury, chronic damages induce pathological changes. The incidence of non-alcoholic fatty liver disease (NAFLD) correlates with the increase in the worldwide obesity epidemic. NAFLD can worsen with the induction of inflammation, leading to the initiation of non-alcoholic steatohepatitis (NASH). These characteristic chronic liver diseases can promote the growth of hepatocellular carcinoma (HCC) for which the only available curative treatments are resection and transplantation.