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Influence of the structure of the sugar moiety on the cytotoxic and antiviral properties of sugar electrophiles

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Published in Chemical and Pharmaceutical Bulletin. 1988, vol. 36, no. 9, p. 3722-3725
Abstract Blocked sugars bearing a 2-nitrovinyl, 1-cyanovinyl, 3-nitrochromen-2-yl or 4-cyano-chromen-2-yl group have been prepared. Their cytotoxicity and chemotherapeutic properties depend on the structure of the sugar moiety. Some of these compounds active against Polyoma virus constitute leads for the development of new antiviral drugs.
Keywords Polyoma virusAntibacterialAlpha-methylideneurononitrileAlpha-methylidenealdononitrileNitrocheomeneCyanochromene
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TRONCHET, Jean Marcel Julien et al. Influence of the structure of the sugar moiety on the cytotoxic and antiviral properties of sugar electrophiles. In: Chemical and Pharmaceutical Bulletin, 1988, vol. 36, n° 9, p. 3722-3725. doi: 10.1248/cpb.36.3722 https://archive-ouverte.unige.ch/unige:127590

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