UNIGE document Scientific Article
previous document  unige:127580  next document
add to browser collection
Title

cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis

Author
Published in EMBO Journal. 1988, vol. 7, no. 10, p. 3189-3197
Abstract Lamins are nucleoskeletal proteins which form intermediate type filaments in close association with the inner nuclear envelope membrane. Based on molecular and biochemical properties the lamins were grouped as type-A and type-B lamins, respectively. I have cloned the cDNA encoding lamin LIII of Xenopus which is the lamin protein present in oocyte nuclei and in cleavage nuclei. The data presented here indicate that a pool of maternal lamin LIII RNA is synthesized very early in oogenesis and that it continues to be present until gastrulation when the vast majority of the LIII RNA is degraded. Despite the similarities shared by all lamin proteins, the lamin LIII sequence neither possesses the features diagnostic for either type-A or type-B lamins nor does it show greater sequence similarity to one of the lamin types than to the other and thus it may represent a third type of lamin protein which may reflect its special function in oogenesis and early development.
Keywords Amino acid sequenceAnimalsBase sequenceNorthern blottingMolecular cloningDNA/geneticsLaminsMolecular sequence dataMolecular weightNuclear proteins/geneticsOogenesisPeptide mappingPrecipitin testsXenopus laevis/embryology/genetics
Identifiers
PMID: 3181134
Full text
Article (Published version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
STICK, Reimer. cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis. In: EMBO Journal, 1988, vol. 7, n° 10, p. 3189-3197. https://archive-ouverte.unige.ch/unige:127580

117 hits

0 download

Update

Deposited on : 2019-12-06

Export document
Format :
Citation style :