Doctoral thesis
Open access

Complementarity of decoupling elements with respect to spectral quality in 2D pure-shift homonuclear experiments

ContributorsBrucka, Marta
Defense date2019-06-14

The work presented in this thesis was aimed at exploring the homodecoupling methods implemented in different two-dimensional NMR experiments. The main goal was to demonstrate the advantages of these experiments in terms of resolution and the information content they provide with respect to “routinely” used experiments. Furthermore, the limitations and complementarity of the methods were investigated. The first part of the work consisted in assembling a toolbox of two-dimensional homonuclear experiments homodecoupled in the F1 indirect dimension (DIAG, CLIP-COSY, TOCSY). The homodecoupling leads to elimination of the J-scalar coupling splitting in the F1 dimension, significantly simplifying the multiplet pattern and reducing the signal overlap probability. In particular, the CLIP-COSY provides in-phase multiplets of a regular lineshape for both diagonal and cross-peaks. While the use of the selective modulated pulse nemoZS or the PSYCHE element ensures the optimal sensitivity, the application of the BIRD filter introduces some novel and interesting features in this experiment and can be used to fully reveal the multiplet structure of signals not easily reachable by other methods. The second part of the work was dedicated to exploiting the toolbox experiments as model sequences in order to examine the spectral artifacts.

Citation (ISO format)
BRUCKA, Marta. Complementarity of decoupling elements with respect to spectral quality in 2D pure-shift homonuclear experiments. 2019. doi: 10.13097/archive-ouverte/unige:127380
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Creation11/25/2019 9:41:00 AM
First validation11/25/2019 9:41:00 AM
Update time03/15/2023 6:30:31 PM
Status update03/15/2023 6:30:30 PM
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