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Clostridium difficile infection is associated with graft loss in solid organ transplant recipients

Cusini, A
Béguelin, C
Stampf, S
Boggian, K
Koller, M
Manuel, O
Meylan, P
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CollaborationWith : Gasche-Soccal, Paola Marina Alessandra
Published in American journal of transplantation. 2018, vol. 18, no. 7, p. 1745-1754
Abstract Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched 2 control subjects per case by age at transplantation, sex, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI. Two thousand one hundred fifty-eight SOT recipients, comprising 87 cases of CDI and 174 matched controls were included. The overall CDI rate per 10 000 patient days was 0.47 (95% confidence interval ([CI] 0.38-0.58), with the highest rate in lung (1.48, 95% CI 0.93-2.24). In multivariable analysis, proven infections (hazard ratio [HR] 2.82, 95% CI 1.29-6.19) and antibiotic treatments (HR 4.51, 95% CI 2.03-10.0) during the preceding 3 months were independently associated with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI posttransplantation had an increased risk of graft loss (HR 2.24, 95% CI 1.15-4.37; P = .02). These findings may help to improve the management of SOT recipients.
PMID: 29349869
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Article (Published version) (342 Kb) - public document Free access
Research groups Groupe Gasche-Soccal Paola (958)
Quorom-sensing et gènes de virulence (301)
Swiss National Science Foundation: Swiss Transplant Cohort Study
(ISO format)
CUSINI, A et al. Clostridium difficile infection is associated with graft loss in solid organ transplant recipients. In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018, vol. 18, n° 7, p. 1745-1754. doi: 10.1111/ajt.14640 https://archive-ouverte.unige.ch/unige:127279

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Deposited on : 2019-12-03

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