Scientific article

Targeting self- and neoepitopes with a modular self-adjuvanting cancer vaccine

Published inJCI Insight, vol. 4, no. 11
Publication date2019

Induction of a potent CD4 and CD8 T-cell response against tumor-specific and tumor-associated antigen is critical for eliminating tumor cells. Recent vaccination strategies have been hampered by an inefficacious and low amplitude immune response. Here we describe a self-adjuvanted chimeric protein vaccine platform to address these challenges, characterized by a multidomain construction incorporating (i) a cell penetrating peptide (CPP) allowing internalization of several multiantigenic Major Histocompatibility Complex (MHC)-restricted peptides within (ii) the multiantigenic domain (Mad) and (iii) a TLR2/4 agonist domain (TLRag). Functionality of the resulting chimeric protein is based on the combined effect of the above-mentioned three different domains for simultaneous activation of antigen presenting cells and antigen cross-presentation, leading to an efficacious multiantigenic and multiallelic cellular immune response. Helper and cytotoxic T-cell responses were observed against model-, neo- and self-antigens, and were highly potent in several murine tumor models. The safety and the immunogenicity of a human vaccine candidate designed for colorectal cancer treatment was demonstrated in a non-human primate model. This newly engineered therapeutic vaccine approach is promising for the treatment of poorly infiltrated tumors that do not respond to currently marketed immunotherapies.

Citation (ISO format)
BELNOUE, Elodie et al. Targeting self- and neoepitopes with a modular self-adjuvanting cancer vaccine. In: JCI Insight, 2019, vol. 4, n° 11. doi: 10.1172/jci.insight.127305
Main files (1)
Article (Published version)
ISSN of the journal2379-3708

Technical informations

Creation11/29/2019 3:44:00 PM
First validation11/29/2019 3:44:00 PM
Update time03/15/2023 6:29:30 PM
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