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Scientific article
Open access
English

RecQ-like helicases: the DNA replication checkpoint connection

Published inJournal of Cell Science, vol. 113, no. 15, p. 2641-2646
Publication date2000
Abstract

The eukaryotic homologues of the Escherichia coli RecQ DNA helicase play conserved roles in the maintenance of genome stability. Results obtained in yeast and mammalian systems are beginning to form a coherent picture about what these helicases do to ensure normal cell division and why humans who lack these enzymes are cancer prone. Recent data suggest that the yeast enzyme Sgs1p, as well as two human homologues, which are encoded by the Bloom's and Werner's syndrome genes, function during DNA replication and possibly in a replication checkpoint specific to S phase.

Keywords
  • Adenosine Triphosphatases/genetics/metabolism
  • Animals
  • Cell Division/physiology
  • DNA Helicases/genetics/metabolism
  • DNA Replication/physiology
  • Eukaryotic Cells/cytology/enzymology
  • Humans
  • RecQ Helicases
  • Sgs1p
  • Helicase
  • Checkpoint
  • S-phase
  • DNA replication
  • Bloom's syndrome
  • Werner's syndrome
Affiliation Not a UNIGE publication
Citation (ISO format)
FREI, Christian, GASSER, Susan Margaret. RecQ-like helicases: the DNA replication checkpoint connection. In: Journal of Cell Science, 2000, vol. 113, n° 15, p. 2641–2646.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0021-9533
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92downloads

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