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Title

Glucotoxicity and pancreatic proteomics

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Published in Journal of Proteomics. 2009, vol. 71, no. 6, p. 576-91
Abstract Chronic hyperglycaemia is one of the main characteristics of a diabetic state. This is also the first cause of diabetic complications. However, it is now generally accepted that glucotoxicity also participates in the worsening of type 2 diabetes, by affecting the secretion of beta-cells. So far, different mechanisms have been proposed to explain the adverse effects of chronic hyperglycaemia. One of them suggests that the modulation of expression of several key proteins during a hyperglycaemia state, may explain the toxic effect of glucotoxicity. Therefore, proteomic analysis of biological samples represents an interesting method to study the effect of chronic hyperglycaemia on protein expression. The discovery of new proteins for which the expression could be modulated by chronic hyperglycaemia may probably help to better understand the mechanisms underlying glucotoxicity. In this review, we will first present an introduction of the different mechanisms known to be involved in the control of glucose homeostasis and in the development of glucotoxicity. In a second part, some proteomic data linked with the effect of glucotoxicity in pancreas, pancreatic islets and beta-cells will be presented and discussed.
Keywords Adipose Tissue/metabolismAnimalsBrain/metabolismDiabetes Mellitus, Type 2Glucagon/metabolismGlucose/metabolism/toxicityHumansInsulin/metabolismIslets of Langerhans/metabolismLiver/metabolismMuscles/metabolismPancreas/metabolismProteome/metabolism
Stable URL https://archive-ouverte.unige.ch/unige:1271
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PMID: 19027091
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Research group Groupe de Protéomique biomédicale (635)

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Deposited on : 2009-03-31

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