Ruling out pulmonary embolism across different subgroups of patients and healthcare settings: protocol for a systematic review and individual patient data meta-analysis (IPDMA)

Geersing, G-J; Kraaijpoel, N; Büller, H R; van Doorn, S; van Es, N; Le Gal, G; Huisman, M V; Kearon, C; Kline, J A; Moons, K G M; Miniati, M; Righini, Marc Philip; Roy, P-M; van der Wall, S J; Wells, P S; Klok, F A

doi:10.1186/s41512-018-0032-7

Scientific article

Meta-analysis

English

Ruling out pulmonary embolism across different subgroups of patients and healthcare settings: protocol for a systematic review and individual patient data meta-analysis (IPDMA)

ContributorsGeersing, G-J; Kraaijpoel, N; Büller, H R; van Doorn, S; van Es, N; Le Gal, G; Huisman, M V; Kearon, C; Kline, J A; Moons, K G M; Miniati, M; Righini, Marc Philip

; Roy, P-M; van der Wall, S J; Wells, P S; Klok, F A

Published inDiagnostic and Prognostic Research, vol. 2, 10

Publication date2018

Abstract

Diagnosing pulmonary embolism in suspected patients is notoriously difficult as signs and symptoms are non-specific. Different diagnostic strategies have been developed, usually combining clinical probability assessment with D-dimer testing. However, their predictive performance differs across different healthcare settings, patient subgroups, and clinical presentation, which are currently not accounted for in the available diagnostic approaches.

Keywords

Clinical prediction model
D-dimer
Individual patient data meta-analysis
Pulmonary embolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Maladie thromboembolique veineuse (808)

Citation (ISO format)

GEERSING, G-J et al. Ruling out pulmonary embolism across different subgroups of patients and healthcare settings: protocol for a systematic review and individual patient data meta-analysis (IPDMA). In: Diagnostic and Prognostic Research, 2018, vol. 2, p. 10. doi: 10.1186/s41512-018-0032-7