Scientific article

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation

Published inAmerican journal of transplantation, vol. 8, no. 12, p. 2674-2683
Publication date2008

Cytomegalovirus (CMV) infection is the most common viral complication after solid organ transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by immunosuppressive therapy remains to be determined. To address this, we compared the genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that the absence of the HLA-C ligand for inhibitory KIR and the presence of activating KIR genes in the recipients were both associated with a lower rate of CMV infection after transplantation. In a cohort of 17 recipients with acute CMV infection, NK cells were phenotyped over a period of time after diagnosis by their expression profile of C-type lectin receptors and capacity to secrete IFN-gamma. The increased expression of the activating C-type lectin receptors NKG2C and NKG2D was paralleled by the decreased IFN-gamma secretion during the early phase of CMV infection. In conclusion, our findings suggest that KIR/HLA genotype and expression of NKG2C and NKG2D might play a significant role in regulating NK cell function and anti-CMV immunity after kidney transplantation.

  • Adult
  • Cytomegalovirus/immunology
  • Cytomegalovirus Infections/epidemiology/immunology
  • Female
  • Genotype
  • HLA-C Antigens/genetics/metabolism
  • Humans
  • Interferon-gamma/metabolism
  • Kidney Transplantation/immunology
  • Killer Cells, Natural/physiology
  • Lectins, C-Type/genetics/metabolism
  • Ligands
  • Male
  • Middle Aged
  • NK Cell Lectin-Like Receptor Subfamily C/genetics/metabolism
  • NK Cell Lectin-Like Receptor Subfamily K/genetics/metabolism
  • Postoperative Complications
  • Receptors, KIR/genetics/metabolism
  • Receptors, Natural Killer Cell/genetics/metabolism
  • Retrospective Studies
  • Risk Factors
Citation (ISO format)
HADAYA, Karine et al. Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. In: American journal of transplantation, 2008, vol. 8, n° 12, p. 2674–2683. doi: 10.1111/j.1600-6143.2008.02431.x
Main files (1)
Article (Accepted version)
ISSN of the journal1600-6135

Technical informations

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