Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study

Ziesenitz, Victoria C; Rodieux, Frédérique; Atkinson, Andrew; Borter, Carole; Bielicki, Julia A; Haschke, Manuel; Duthaler, Urs; Bachmann, Fabio; Erb, Thomas O; Gürtler, Nicolas; Holland-Cunz, Stefan; van den Anker, Johannes N; Gotta, Verena; Pfister, Marc

doi:10.1007/s00228-019-02720-2

Scientific article

English

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study

ContributorsZiesenitz, Victoria C; Rodieux, Frédérique; Atkinson, Andrew; Borter, Carole; Bielicki, Julia A; Haschke, Manuel; Duthaler, Urs; Bachmann, Fabio; Erb, Thomas O; Gürtler, Nicolas; Holland-Cunz, Stefan; van den Anker, Johannes N; Gotta, Verena; Pfister, Marc

Published inEuropean Journal of Clinical Pharmacology, vol. 75, no. 11, p. 1491-1502

Publication date2019

Abstract

The prodrug metamizole is prescribed intravenously for postoperative pain in children, including off-label use in infants < 1 year. We aimed to assess the pharmacokinetics of the main metabolites of metamizole in children aged 3-72 months.

Keywords

Children
Dipyrone
Infants
Metamizole
Pharmacokinetics

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

Groupe Desmeules Jules (pharmacologie/toxicologie) (567)

Funding

Swiss National Science Foundation - 31003A_160216

Citation (ISO format)

ZIESENITZ, Victoria C et al. Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study. In: European Journal of Clinical Pharmacology, 2019, vol. 75, n° 11, p. 1491–1502. doi: 10.1007/s00228-019-02720-2

Article (Published version)

Supplemental data

Identifiers

PID : unige:126992
DOI : 10.1007/s00228-019-02720-2
PMID : 31388703

Journal ISSN0031-6970

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Creation25/11/2019 14:37:00

First validation25/11/2019 14:37:00

Update15/03/2023 18:27:46

Status update15/03/2023 18:27:45

Last indexation31/10/2024 17:02:59

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Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study

The prodrug metamizole is prescribed intravenously for postoperative pain in children, including off-label use in infants < 1 year. We aimed to assess the pharmacokinetics of the main metabolites of metamizole in children aged 3-72 months.

Technical informations