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Title

Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?
Author
Scorrano, Luca
Published in The Journal of Cell Biology. 2008, vol. 183, no. 4, p. 579-581
Abstract In certain cell types, apoptosis in response to extracellular stimuli like Fas depends on a mitochondrial amplificatory loop: the apical caspase-8 cleaves and activates the BH3-only member of the Bcl-2 family BID. In turn, BID induces the release of cytochrome c from mitochondria to the cytoplasm, where it is required to fully activate effector caspases. In this issue of The Journal of Cell Biology, Gonzalvez et al. (see p. 681) show that when caspase-8 activation and production of functional BID is required, it is performed on mitochondrial platforms provided by the mitochondrion-specific lipid cardiolipin. Cardiolipin anchors caspase-8 at contact sites between inner and outer mitochondrial membranes, facilitating its self activation. These findings suggests that like other second messengers such as Ca(2+) and cAMP, production of apoptotic messengers can be compartmentalized in close proximity to their intracellular target.
Keywords Antigens, CD95/genetics/metabolism — Apoptosis/physiology — Cardiolipins/genetics/metabolism — Caspase 8/genetics/metabolism — Hela Cells — Humans — Mitochondria/enzymology/metabolism — Mitochondrial Membranes/enzymology — Mitochondrial Proteins/genetics/metabolism — Protein Transport/physiology — Transcription Factors/genetics/metabolism
Identifiers
PMID: 19001131
Full text
Article (Author postprint) (672 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Supplemental data (144 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://jcb.rupress.org/cgi/content/full/183/4/579
Structures
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research group Les mitochondries dans la vie cellulaire (850)
Citation
(ISO format) 		SCORRANO, Luca. Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?. In: The Journal of Cell Biology, 2008, vol. 183, n° 4, p. 579-581. https://archive-ouverte.unige.ch/unige:1264

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Deposited on : 2009-03-31

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