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Wipe-sampling procedure optimisation for the determination of 23 antineoplastic drugs used in the hospital pharmacy

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Published in European Journal of Hospital Pharmacy. Science and Practice. 2019, p. 1-6
Abstract Purpose: Optimise a wipe sampling procedure to evaluate the surface contamination for 23 antineoplastic drugs used in the hospital pharmacy. Methods: The influence of various parameters (ie, sampling device, sampling solution, desorption modes) was evaluated using a validated liquid chromatography–mass spectrometry (LC-MS/MS) method able to quantify 23 antineoplastic drugs widely used in the hospital pharmacy: 5-fluorouracil, busulfan, cyclophosphamide, cytarabine, dacarbazine, daunorubicin, docetaxel, doxorubicin, epirubicin, etoposide, etoposide phosphate, fludarabine phosphate, ganciclovir, gemcitabine, idarubicin, ifosfamide, irinotecan, methotrexate, paclitaxel, pemetrexed, raltitrexed, topotecan and vincristine. Best conditions were tested with real samples from a hospital pharmacy chemotherapy compounding unit. Results: Polyester swabs (TX714 and TX716) gave satisfactory results for the desorption step for all compounds with mean recoveries of 90% and 95%, respectively. For the wiping step, higher recoveries were obtained using TX716 and isopropanol 75% as wiping solution. As anticipated, most intense contaminations were found close to the chemotherapy production site, on surfaces the most frequently in contact with operators’ hands. Conclusion: Wipe sampling method was successfully developed and applied to real samples to determine surface contamination with 23 antineoplastic agents in trace amounts.
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Research group Pharmacie hospitalière et clinique
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GUICHARD, Nicolas et al. Wipe-sampling procedure optimisation for the determination of 23 antineoplastic drugs used in the hospital pharmacy. In: European Journal of Hospital Pharmacy. Science and Practice, 2019, p. 1-6. doi: 10.1136/ejhpharm-2019-001983 https://archive-ouverte.unige.ch/unige:126339

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Deposited on : 2019-11-15

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