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Autologous Platelet-Rich Plasma (CuteCell PRP) Safely Boosts In Vitro Human Fibroblast Expansion

Turzi, Antoine
Published in Tissue engineering. Part A. 2019, vol. 25, no. 21-22, p. 1550-1563
Abstract Autologous dermal fibroblast graft is an important therapy in skin defect repair, but in vitro skin cell culture is mandatory in most cases. However, cell expansion using xenogeneic/allogenic culture media presents some disadvantages, such as the risk of infection transmission. We demonstrated that an autologous culture system with the patient's own platelet-rich plasma is an efficient, cost-effective, and safe supplement for fibroblast culture. As it respects the good manufacturing practices and regulatory agencies standards, it should be considered as a potent alternative and substitute to xenogeneic or allogenic blood derivatives for the validation of future clinical protocols using in vitro cell expansion.
Keywords Platelet-rich plasmaPRPFibroblastsCell proliferationCell migrationWound healingCell cultureCell therapy
PMID: 30896295
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Research group Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)
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BERNDT, Sarah et al. Autologous Platelet-Rich Plasma (CuteCell PRP) Safely Boosts In Vitro Human Fibroblast Expansion. In: Tissue engineering. Part A, 2019, vol. 25, n° 21-22, p. 1550-1563. doi: 10.1089/ten.TEA.2018.0335 https://archive-ouverte.unige.ch/unige:126315

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Deposited on : 2019-11-15

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