UNIGE document Scientific Article
previous document  unige:126162  next document
add to browser collection
Title

Xenogeneic Heterotopic Auxiliary Liver transplantation (XHALT) promotes native liver regeneration in a Post-Hepatectomy Liver failure model

Authors
Navarro-Alvarez, Nalu
Machaidze, Zurab
Zhu, Alexander
Liu, Wei-Hui
Shah, Jigesh A
Vagefi, Parsia A
Elias, Nahel
show hidden authors show all authors [1 - 12]
Published in PLOS ONE. 2018, vol. 13, no. 11, p. e0207272
Abstract The liver's regenerative capacity is unique, but too small a segment can overwhelm its ability to simultaneously regenerate and support the host, resulting in liver dysfunction and death. Here we tested a temporary Xenogeneic Heterotopic Auxiliary Liver Transplant (XHALT) from Gal-KO miniature swine in a baboon model of Post-Hepatectomy Liver Failure (PHLF) by 90%- hepatectomy. Immunosuppression consisted of CVF, ATG, FK 506 and steroids. 90%-hepatectomized animals died within 4-5 days with the clinical picture of PHLF, (high LFTs and bilirubin, ascites, encephalopathy and coagulopathy). The 10% remnants had macroscopic and histological evidence of severe steatosis and absence of hepatocyte replication. In contrast, the addition of XHALT prolonged survival up to 11 days, with the cause of death being sepsis, rather than liver failure. The remnant liver appeared grossly normal, and on histology, there was no evidence of fatty infiltration, but there was pronounced Ki-67 staining. In conclusion, temporary auxiliary xenografts have the potential to support a small for size liver graft while it grows to adequate size or provide an opportunity for organ recovery in acute liver failure.
Keywords Fatty liverLiver transplantationSwineHepatocytesHistologyBaboonsSurgical and invasive medical proceduresHepatectomy
Identifiers
PMID: 30462716
Full text
Structures
Research group Cultures cellulaires et transplantations (519)
Citation
(ISO format)
NAVARRO-ALVAREZ, Nalu et al. Xenogeneic Heterotopic Auxiliary Liver transplantation (XHALT) promotes native liver regeneration in a Post-Hepatectomy Liver failure model. In: PLOS ONE, 2018, vol. 13, n° 11, p. e0207272. doi: 10.1371/journal.pone.0207272 https://archive-ouverte.unige.ch/unige:126162

141 hits

60 downloads

Update

Deposited on : 2019-11-13

Export document
Format :
Citation style :