Since decades, implantology is predominantly dominated by titanium thanks to its mechanical and biological properties. However, questions related to its ageing and its resistance to corrosion have rarely been asked. A phenomenon named tribocorrosion was reported in the recent literature resulting in the release of titanium particles into the soft tissues and the bone. The scientific evidence has shown particles could interact with osteoclasts, affect the cellular homeostasis of fibroblasts and promote inflammatory reactions. Regarding any allergic reactions to titanium, data remained limited and subject to controversy in their interpretation. Nowadays, titanium dioxide is commonly used by the food, cosmetic and pharmaceutic industry.