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The network integration of epileptic activity in relation to surgical outcome

Toscano, Gianpaolo
Tourbier, Sébastien
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Published in Clinical Neurophysiology. 2019, vol. 130, no. 12, p. 2193-2202
Abstract Objective: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks. Methods: We analysed 19 patients with focal epilepsy who had high-density EEG containing IED and underwent surgery. We estimated cortical activity during IED using electric source analysis in 72 atlas-based cortical regions of the individual brain MRI. We applied directed connectivity analysis (information Partial Directed Coherence) and graph analysis on these sources and compared patients with good vs poor post-operative outcome at global, hemispheric and lobar level. Results: We found lower network integration reflected by global, hemispheric, lobar efficiency during the IED (p<0.05) in patients with good post-surgical outcome, compared to patients with poor outcome. Prediction was better than using the IED field or the localisation obtained by electric source imaging. Conclusions: Abnormal network patterns in epilepsy are related to seizure outcome after surgery. Significance: Our finding may help understand networks related to a more “isolated” epileptic activity, limiting the extent of the epileptic network in patients with subsequent good post-operative outcome.
Keywords EpilepsySource localizationConnectivityNetwork integrationGlobal Efficiency
PMID: 31669753
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Research groups Epilepsie et réseaux cérébraux (1002)
Organisation et plasticité des réseaux neuronaux cérébraux (148)
Epilepsie et Chirurgie (149)
Groupe Schaller Karl Lothard (neurochirurgie) (851)
Projects FNS: CRSII5_170873
FNS: 169198
FNS: 163398
FNS: Sinergia 180365
(ISO format)
CARBONI, Margherita et al. The network integration of epileptic activity in relation to surgical outcome. In: Clinical Neurophysiology, 2019, vol. 130, n° 12, p. 2193-2202. doi: 10.1016/j.clinph.2019.09.006 https://archive-ouverte.unige.ch/unige:125614

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Deposited on : 2019-11-05

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