en
Scientific article
Review
Open access
English

Individualized immunological data for precise classification of OCD patients

Published inBrain Sciences, vol. 8, no. 8, E149
Publication date2018
Abstract

Obsessive⁻compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

Keywords
  • Psychiatry
  • OCD
  • Obsessive–compulsive disorder
  • Tourette syndrome
  • Immunology
  • Cytokines
  • Pediatric autoimmune neuropsychological disorders associated with streptococcal
  • Infection (PANDAS)
  • Pediatric acute-onset neuropsychiatric syndrome (PANS)
  • Toxoplasma gondii
  • Streptococcus pyogenes
Citation (ISO format)
LAMOTHE, Hugues et al. Individualized immunological data for precise classification of OCD patients. In: Brain Sciences, 2018, vol. 8, n° 8, p. E149. doi: 10.3390/brainsci8080149
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Article (Published version)
Identifiers
ISSN of the journal2076-3425
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157downloads

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