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Individualized immunological data for precise classification of OCD patients

Lamothe, Hugues
Baleyte, Jean-Marc
Smith, Pauline
Pelissolo, Antoine
Published in Brain sciences. 2018, vol. 8, no. 8, E149
Abstract Obsessive⁻compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.
Keywords PsychiatryOCDObsessive–compulsive disorderTourette syndromeImmunologyCytokinesPediatric autoimmune neuropsychological disorders associated with streptococcalInfection (PANDAS)Pediatric acute-onset neuropsychiatric syndrome (PANS)Toxoplasma gondiiStreptococcus pyogenes
PMID: 30096863
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Research group Médecine psychosomatique, neurosciences cliniques et mindfulness (690)
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LAMOTHE, Hugues et al. Individualized immunological data for precise classification of OCD patients. In: Brain Sciences, 2018, vol. 8, n° 8, p. E149. doi: 10.3390/brainsci8080149 https://archive-ouverte.unige.ch/unige:125294

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Deposited on : 2019-10-30

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