HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase

Luban, Jeremy

doi:10.1016/j.cub.2008.07.037

Scientific article

English

HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase

ContributorsLuban, Jeremy

Published inCurrent biology, vol. 18, no. 16, p. R710-713

Publication date2008

Abstract

Factors necessary for HIV-1 nuclear import have been sought for many years. Recent reports suggest that TNPO3/Transportin-SR2 binds to HIV-1 integrase and is required for HIV-1 infection of interphase cells.

Keywords

Cell Nucleus/metabolism/virology
HIV Integrase/metabolism
HIV-1/metabolism/physiology
Virus Replication
Beta Karyopherins/metabolism

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Research groups

Réplication virale, pathogénèse et immunité (848)

Citation (ISO format)

LUBAN, Jeremy. HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase. In: Current biology, 2008, vol. 18, n° 16, p. R710–713. doi: 10.1016/j.cub.2008.07.037

Article (Accepted version)

Identifiers

PID : unige:1249
DOI : 10.1016/j.cub.2008.07.037
PMID : 18727908

Journal ISSN0960-9822

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HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase

Factors necessary for HIV-1 nuclear import have been sought for many years. Recent reports suggest that TNPO3/Transportin-SR2 binds to HIV-1 integrase and is required for HIV-1 infection of interphase cells.

Technical informations