Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes

Sinturel, Flore; Makhlouf, Anne-Marie; Meyer, Patrick; Tran, Christel; Pataky, Zoltan; Golay, Alain; Rey, Guillaume; Howald, Cédric; Dermitzakis, Emmanouil; Pichard, Claude; Philippe, Jacques; Brown, Steven A; Dibner, Charna

doi:10.1007/s00125-019-4907-0

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Title		Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes
Authors		Sinturel, Flore Makhlouf, Anne-Marie Meyer, Patrick Tran, Christel Pataky, Zoltan Golay, Alain Rey, Guillaume Howald, Cédric Dermitzakis, Emmanouil Pichard, Claude Philippe, Jacques Brown, Steven A Dibner, Charna show all authors [1 - 13]
Published in		Diabetologia. 2019, vol. 62, no. 8, p. 1453-1462
Abstract		The circadian system plays an essential role in regulating the timing of human metabolism. Indeed, circadian misalignment is strongly associated with high rates of metabolic disorders. The properties of the circadian oscillator can be measured in cells cultured in vitro and these cellular rhythms are highly informative of the physiological circadian rhythm in vivo. We aimed to discover whether molecular properties of the circadian oscillator are altered as a result of type 2 diabetes.
Identifiers		DOI: 10.1007/s00125-019-4907-0 PMID: 31134308
Full text		Article (Published version) (971 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Centres et instituts / Institut de génétique et de génomique
Research groups		Education thérapeutique du patient, diabète et obésité (600) Endocrinologie et horloge circadienne (948) Nutrition clinique (597)
Project		Swiss National Science Foundation: Sinergia CRSII3_160741
Citation (ISO format)		SINTUREL, Flore et al. Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes. In: Diabetologia, 2019, vol. 62, n° 8, p. 1453-1462. doi: 10.1007/s00125-019-4907-0 https://archive-ouverte.unige.ch/unige:124844