Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes

Sinturel, Flore; Makhlouf, Anne-Marie; Meyer, Patrick; Tran, Christel; Pataky, Zoltan; Golay, Alain; Rey, Guillaume; Howald, Cédric; Dermitzakis, Emmanouil; Pichard, Claude; Philippe, Jacques; Brown, Steven A; Dibner, Charna

doi:10.1007/s00125-019-4907-0

Scientific article

English

Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes

ContributorsSinturel, Flore; Makhlouf, Anne-Marie; Meyer, Patrick; Tran, Christel; Pataky, Zoltan

; Golay, Alain; Rey, Guillaume; Howald, Cédric; Dermitzakis, Emmanouil; Pichard, Claude; Philippe, Jacques; Brown, Steven A; Dibner, Charna

Published inDiabetologia, vol. 62, no. 8, p. 1453-1462

Publication date2019

Abstract

The circadian system plays an essential role in regulating the timing of human metabolism. Indeed, circadian misalignment is strongly associated with high rates of metabolic disorders. The properties of the circadian oscillator can be measured in cells cultured in vitro and these cellular rhythms are highly informative of the physiological circadian rhythm in vivo. We aimed to discover whether molecular properties of the circadian oscillator are altered as a result of type 2 diabetes.

Affiliation entities

Research groups

Funding

Swiss National Science Foundation - Sinergia CRSII3_160741

Citation (ISO format)

SINTUREL, Flore et al. Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes. In: Diabetologia, 2019, vol. 62, n° 8, p. 1453–1462. doi: 10.1007/s00125-019-4907-0

Article (Published version)

Identifiers

PID : unige:124844
DOI : 10.1007/s00125-019-4907-0
PMID : 31134308

Journal ISSN0012-186X

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Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes

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