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Title

Usefulness of a systematic approach at listing for vaccine prevention in solid organ transplant candidates

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Published in American journal of transplantation. 2019, vol. 19, no. 2, p. 512-521
Abstract Solid organ transplant (SOT) candidates may not be immune against potentially vaccine-preventable diseases because of insufficient immunizations and/or limited vaccine responses. We evaluated the impact on vaccine immunity at transplant of a systematic vaccinology workup at listing that included (1) pneumococcal with and without influenza immunization, (2) serology-based vaccine recommendations against measles, varicella, hepatitis B virus, hepatitis A virus, and tetanus, and (3) the documentation of vaccines and serology tests in a national electronic immunization registry (www.myvaccines.ch). Among 219 SOT candidates assessed between January 2014 and November 2015, 54 patients were transplanted during the study. Between listing and transplant, catch-up immunizations increased the patients' immunity from 70% to 87% (hepatitis A virus, P = .008), from 22% to 41% (hepatitis B virus, P = .008), from 77% to 91% (tetanus, P = .03), and from 78% to 98% (Streptococcus pneumoniae, P = .002). Their immunity at transplant was significantly higher against S. pneumoniae (P = .006) and slightly higher against hepatitis A virus (P = .07), but not against hepatitis B virus, than that of 65 SOT recipients transplanted in 2013. This demonstrates the value of a systematic multimodal serology-based approach of immunizations of SOT candidates at listing and the need for optimized strategies to increase their hepatitis B virus vaccine responses.
Keywords Clinical research/practiceInfectious diseaseOrgan transplantation in generalPreventive healthcareVaccine
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PMID: 30144276
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Article (Published version) (382 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Supplemental data (17 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.15097
Structures
Research groups Epidémiologie clinique et biostatistique (115)
La transplantation d'îlots de Langerhans (623)
Quorom-sensing et gènes de virulence (301)
Centre de vaccinologie et d'immunologie néonatale (177)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
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(ISO format)
BLANCHARD ROHNER, Géraldine et al. Usefulness of a systematic approach at listing for vaccine prevention in solid organ transplant candidates. In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019, vol. 19, n° 2, p. 512-521. doi: 10.1111/ajt.15097 https://archive-ouverte.unige.ch/unige:124701

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Deposited on : 2019-10-21

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