Linking toxin-antitoxin systems with phenotypes: A Staphylococcus aureus viewpoint

Sierra Miranda, Roberto Mario; Viollier, Patrick; Renzoni, Adriana Maria

doi:10.1016/j.bbagrm.2018.07.009

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Title		Linking toxin-antitoxin systems with phenotypes: A Staphylococcus aureus viewpoint
Authors		Sierra Miranda, Roberto Mario Viollier, Patrick Renzoni, Adriana Maria
Published in		Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2019, vol. 1862, no. 7, p. 742-751
Abstract		Toxin-antitoxin systems (TAS) are genetic modules controlling different aspects of bacterial physiology. They operate with versatility in an incredibly wide range of mechanisms. New TA modules with unexpected functions are continuously emerging from genome sequencing projects. Their discovery and functional studies have shed light on different characteristics of bacterial metabolism that are now applied to understanding clinically relevant questions and even proposed as antimicrobial treatment. Our main source of knowledge of TA systems derives from Gram-negative bacterial studies, but studies in Gram-positives are becoming more prevalent and provide new insights to TA functional mechanisms. In this review, we present an overview of the present knowledge of TA systems in the clinical pathogen Staphylococcus aureus, their implications in bacterial physiology and discuss relevant aspects that are driving TAS research. "This article is part of a Special Issue entitled: Dynamic gene expression, edited by Prof. Patrick Viollier".
Identifiers		DOI: 10.1016/j.bbagrm.2018.07.009 PMID: 30056132
Full text		Article (Published version) (1.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Régulation du cycle cellulaire dans C.crescentus, une bactérie asymétrique (895)
Project		Swiss National Science Foundation: 310030-14940
Citation (ISO format)		SIERRA MIRANDA, Roberto Mario, VIOLLIER, Patrick, RENZONI, Adriana Maria. Linking toxin-antitoxin systems with phenotypes: A Staphylococcus aureus viewpoint. In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 2019, vol. 1862, n° 7, p. 742-751. doi: 10.1016/j.bbagrm.2018.07.009 https://archive-ouverte.unige.ch/unige:124290