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The Candidate Schizophrenia Risk Gene DGCR2 Regulates Early Steps of Corticogenesis

Published inBiological Psychiatry, vol. 83, no. 8, p. 692-706
Publication date2018
Abstract

Alterations in early steps of cortical circuit assembly are thought to play a critical role in vulnerability to schizophrenia (SZ), but the pathogenic impact of SZ-risk mutations on corticogenesis remains to be determined. DiGeorge syndrome critical region 2 (DGCR2) is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ. Moreover, exome sequencing of individuals with idiopathic SZ identified a rare missense mutation in DGCR2, further suggesting that DGCR2 is involved in SZ.

Keywords
  • 22q11
  • Corticogenesis
  • DGCR2
  • Neuronal migration
  • Reelin
  • Schizophrenia
Citation (ISO format)
MOLINARD-CHENU, Aude, DAYER, Alexandre. The Candidate Schizophrenia Risk Gene DGCR2 Regulates Early Steps of Corticogenesis. In: Biological Psychiatry, 2018, vol. 83, n° 8, p. 692–706. doi: 10.1016/j.biopsych.2017.11.015
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ISSN of the journal0006-3223
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