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Scientific article
French

Hu antigen R (HuR) heterogeneous expression quantification as a prognostic marker of melanoma

Published inJournal of Cutaneous Pathology, vol. 45, no. 5, p. 333-336
Publication date2018
Abstract

Prognostic markers for melanoma, particularly for stage II disease, are needed for the risk‐benefit evaluation of future adjuvant therapies. The mainly nuclear RNA‐binding protein human antigen R (HuR) regulates the protein expression of thousands of mRNAs, its own heterogeneous expression could therefore reflect tumor heterogeneity and plasticity. Here, we evaluate its quantification in primary melanoma as a marker of metastatic outcome.

Keywords
  • Automated signal quantification
  • HuR
  • kurtosis
  • melanoma
  • tumor heterogeneity
Funding
  • Swiss National Science Foundation - M.F. was supported by the Swiss National Science Foundation
Citation (ISO format)
LIAUDET, Nicolas et al. Hu antigen R (HuR) heterogeneous expression quantification as a prognostic marker of melanoma. In: Journal of Cutaneous Pathology, 2018, vol. 45, n° 5, p. 333–336. doi: 10.1111/cup.13119
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Article (Published version)
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Identifiers
ISSN of the journal0303-6987
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Technical informations

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