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Effect of implantation site on outcome of tissue-engineered vascular grafts

Saat, Shahrul A
Dillon, Jeswant
Yakub, Azhari
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Published in European Journal of Pharmaceutics and Biopharmaceutics. 2019, vol. 139, p. 272-278
Abstract Vascular prostheses for small caliber bypass grafts in cardiac and vascular diseases or for access surgery are still missing. Poly (Ɛ-caprolactone) (PCL) has been previously investigated by our group and showed good biocompatibility and mechanical properties in vitro and rapid endothelialisation, cellular infiltration and vascularisation in vivo yielding optimal patency in the abdominal aortic position. The aim of the present study is to evaluate our PCL graft in the carotid position and to compare its outcome to the grafts implanted in the abdominal aortic position.
Keywords AnimalsAortaAbdominal/physiopathology/surgeryBlood Vessel Prosthesis/adverse effectsBlood Vessel Prosthesis Implantation/adverse effects/instrumentation/methodsCaproates/chemistryCarotid Arteries/physiopathology/surgeryGraft OcclusionVascular/diagnostic imaging/etiology/physiopathologyLactones/chemistryModelsAnimalPolyesters/chemistryRatsRatsSprague-DawleyVascular Patency
PMID: 31004790
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FNS: 320030-119822
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SOLOGASHVILI, Tornike et al. Effect of implantation site on outcome of tissue-engineered vascular grafts. In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 272-278. doi: 10.1016/j.ejpb.2019.04.012 https://archive-ouverte.unige.ch/unige:123525

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Deposited on : 2019-09-24

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