en
Scientific article
English

Effect of implantation site on outcome of tissue-engineered vascular grafts

Publication date2019
Abstract

Vascular prostheses for small caliber bypass grafts in cardiac and vascular diseases or for access surgery are still missing. Poly (Ɛ-caprolactone) (PCL) has been previously investigated by our group and showed good biocompatibility and mechanical properties in vitro and rapid endothelialisation, cellular infiltration and vascularisation in vivo yielding optimal patency in the abdominal aortic position. The aim of the present study is to evaluate our PCL graft in the carotid position and to compare its outcome to the grafts implanted in the abdominal aortic position.

Keywords
  • Animals
  • Aorta
  • Abdominal/physiopathology/surgery
  • Blood Vessel Prosthesis/adverse effects
  • Blood Vessel Prosthesis Implantation/adverse effects/instrumentation/methods
  • Caproates/chemistry
  • Carotid Arteries/physiopathology/surgery
  • Graft Occlusion
  • Vascular/diagnostic imaging/etiology/physiopathology
  • Lactones/chemistry
  • Models
  • Animal
  • Polyesters/chemistry
  • Rats
  • Rats
  • Sprague-Dawley
  • Vascular Patency
Funding
  • Swiss National Science Foundation - Drug eluting cardiovascular prosthesis using nanofibre-structured biodegradable polymers
Citation (ISO format)
SOLOGASHVILI, Tornike et al. Effect of implantation site on outcome of tissue-engineered vascular grafts. In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 272–278. doi: 10.1016/j.ejpb.2019.04.012
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0939-6411
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1downloads

Technical informations

Creation09/24/2019 3:39:00 PM
First validation09/24/2019 3:39:00 PM
Update time03/15/2023 6:03:43 PM
Status update03/15/2023 6:03:43 PM
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