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Recent developments in drug-induced movement disorders: a mixed picture

Factor, Stewart A
Caroff, Stanley
Friedman, Joseph H
Marras, Connie
Tinazzi, Michele
Comella, Cynthia L
Published in The Lancet neurology. 2019, vol. 18, no. 9, p. 880-890
Abstract A large and ever-growing number of medications can induce various movement disorders. Drug-induced movement disorders are disabling but are often under-recognised and inappropriately managed. In particular, second generation antipsychotics, like first generation agents, are associated with potentially debilitating side-effects, most notably tardive syndromes and parkinsonism, as well as potentially fatal acute syndromes. Appropriate, evidence-based management is essential as these drugs are being prescribed to a growing population vulnerable to these side-effects, including children and elderly people. Prevention of the development of drug-induced movement disorders is an important consideration when prescribing medications that can induce movement disorders. Recent developments in diagnosis, such as the use of dopamine transporter imaging for drug-induced parkinsonism, and treatment, with the approval of valbenazine and deutetrabenazine, the first drugs indicated for tardive syndromes, have improved outcomes for many patients with drug-induced movement disorders. Future research should focus on development of safer antipsychotics and specific therapies for the different tardive syndromes and the treatment of drug-induced parkinsonism.
PMID: 31279747
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Research group Groupe Pierre Burkhard (neurologie) (154)
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FACTOR, Stewart A et al. Recent developments in drug-induced movement disorders: a mixed picture. In: The Lancet Neurology, 2019, vol. 18, n° 9, p. 880-890. doi: 10.1016/S1474-4422(19)30152-8 https://archive-ouverte.unige.ch/unige:123501

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Deposited on : 2019-09-23

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