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Signaling cascades governing entry into and exit from host cells by toxoplasma gondii

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Published in Annual Review of Microbiology. 2019, vol. 73, p. 579-599
Abstract The Apicomplexa phylum includes a large group of obligate intracellular protozoan parasites responsible for important diseases in humans and animals. Toxoplasma gondii is a widespread parasite with considerable versatility, and it is capable of infecting virtually any warm-blooded animal, including humans. This outstanding success can be attributed at least in part to an efficient and continuous sensing of the environment, with a ready-to-adapt strategy. This review updates the current understanding of the signals governing the lytic cycle of T. gondii, with particular focus on egress from infected cells, a key step for balancing survival, multiplication, and spreading in the host. We cover the recent advances in the conceptual framework of regulation of microneme exocytosis that ensures egress, motility, and invasion. Particular emphasis is given to the trigger molecules and signaling cascades regulating exit from host cells.
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PMID: 31500539
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Article (Published version) (803 Kb) - public document Free access
Structures
Research group Biologie d'un parasite intracellulaire obligatoire (773)
Projects FNS: FN3100A0-116722
H2020: ToxoPersist
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(ISO format)
BISIO SABARIS, Hugo, SOLDATI-FAVRE, Dominique. Signaling cascades governing entry into and exit from host cells by toxoplasma gondii. In: Annual Review of Microbiology, 2019, vol. 73, p. 579-599. doi: 10.1146/annurev-micro-020518-120235 https://archive-ouverte.unige.ch/unige:123112

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Deposited on : 2019-09-13

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