en
Scientific article
Review
Open access
English

How HSCs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective

Publication date2019
Abstract

Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex vivo, creating a need to further understand HSC expansion in vivo. After embryonic HSCs are born from the hemogenic endothelium, they migrate to the embryonic/fetal niche, where the future adult HSC pool is established by considerable expansion. This takes place at different anatomical sites and is controlled by numerous signals. HSCs then migrate to their adult niche, where they are maintained throughout adulthood. Exactly how HSC expansion is controlled during embryogenesis remains to be characterized and is an important step to improve the therapeutic use of HSCs. We will review the current knowledge of HSC expansion in the different fetal niches across several model organisms and highlight possible clinical applications.

Funding
  • Swiss National Science Foundation - 31003_166515
Citation (ISO format)
MAHONY, Christopher, BERTRAND, Julien. How HSCs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective. In: Frontiers in Cell and Developmental Biology, 2019, vol. 7, p. 34. doi: 10.3389/fcell.2019.00034
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2296-634X
319views
195downloads

Technical informations

Creation09/02/2019 2:10:00 PM
First validation09/02/2019 2:10:00 PM
Update time03/15/2023 5:58:43 PM
Status update03/15/2023 5:58:43 PM
Last indexation05/05/2024 3:13:52 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack