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Title

Catalytic Asymmetric Bromine-Lithium Exchange: A New Tool to Build Axial Chirality

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Published in Advanced Synthesis and Catalysis. 2010, vol. 352, no. 14-15, p. 2611 - 2620
Abstract We present here the first catalytic desymmetrization of the 2,2',6,6'-tetrabromobiphenyl 1 and analogues, by a bromine-lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).
Keywords Asymmetric catalysisAtropoisomerismBiarylsDiphosphinesMetal-halogen exchange
Stable URL https://archive-ouverte.unige.ch/unige:12231
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Other version: http://doi.wiley.com/10.1002/adsc.201000517
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Deposited on : 2010-10-22

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