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Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl Alanes to Trisubstituted Enones: Binap as an Effective Ligand in the Formation of Quaternary Stereocenters

Müller, Daniel
Felouat, Abdellah
Woodward, Simon
Published in Angewandte Chemie: International Edition. 2010, vol. 49, no. 42, p. 7769 - 7772
Abstract All for one and 1,4-all: Readily available aryl alanes are used in the rhodium-catalyzed asymmetric conjugate addition reaction with a variety of cyclic and acyclic enones. The enhanced reactivity of the system allows the use of the common binap ligand for the generation of quaternary benzylic stereocenters in excellent enantioselectivity (see scheme).
Keywords Aryl alanesAsymmetric catalysisMichael additionQuaternary stereocentersRhodium
Stable URL https://archive-ouverte.unige.ch/unige:12230
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Other version: http://doi.wiley.com/10.1002/anie.201003300

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Deposited on : 2010-10-22

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