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Scientific article
English

Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl Alanes to Trisubstituted Enones: Binap as an Effective Ligand in the Formation of Quaternary Stereocenters

Published inAngewandte Chemie, vol. 49, no. 42, p. 7769-7772
Publication date2010
Abstract

All for one and 1,4-all: Readily available aryl alanes are used in the rhodium-catalyzed asymmetric conjugate addition reaction with a variety of cyclic and acyclic enones. The enhanced reactivity of the system allows the use of the common binap ligand for the generation of quaternary benzylic stereocenters in excellent enantioselectivity (see scheme).

Keywords
  • Aryl alanes
  • Asymmetric catalysis
  • Michael addition
  • Quaternary stereocenters
  • Rhodium
Citation (ISO format)
HAWNER, Christine et al. Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl Alanes to Trisubstituted Enones: Binap as an Effective Ligand in the Formation of Quaternary Stereocenters. In: Angewandte Chemie, 2010, vol. 49, n° 42, p. 7769–7772. doi: 10.1002/anie.201003300
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ISSN of the journal1433-7851
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Creation10/21/2010 5:31:00 PM
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